Extracellular vesicles as antigen carriers for novel vaccination avenues
نویسندگان
چکیده
Antigen delivery has always been a challenge in scientific practice of vaccine formulation. Yet, mammalian extracellular vesicles (EVs) or bacterial membrane (MVs) provide an innovative avenue for safe and effective antigenic material. They include intrinsically loaded antigens from EV-secreting cells extrinsically onto pre-formed vesicles. Interestingly, many studies shed light on potential novel anti-cancer vaccination immunotherapy therapeutic applications cell host-derived EVs, as well conventional prophylactic using cell-derived MVs against infectious diseases. Here, we discuss the rationale, status quo both EVs.
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2021
ISSN: ['1872-8294', '0169-409X']
DOI: https://doi.org/10.1016/j.addr.2021.03.016